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Kohji Itoh Selected Research

Fluorouracil (Carac)

6/2011Up-regulation of insulin-like growth factor-binding protein 3 by 5-fluorouracil (5-FU) leads to the potent anti-proliferative effect of androgen deprivation therapy combined with 5-FU in human prostate cancer cell lines.
3/2011Hydroxyflutamide enhances cellular sensitivity to 5-fluorouracil by suppressing thymidylate synthase expression in bicalutamide-resistant human prostate cancer cells.

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Kohji Itoh Research Topics

Disease

16Sandhoff Disease (Sandhoff's Disease)
01/2018 - 01/2005
11Neuraminidase deficiency with beta-galactosidase deficiency
06/2022 - 01/2002
10Lysosomal Storage Diseases (Lysosomal Storage Disease)
01/2019 - 03/2005
8GM2 Gangliosidoses (GM2 Gangliosidosis)
09/2016 - 08/2006
5Neoplasms (Cancer)
07/2021 - 12/2006
5Tay-Sachs Disease
06/2011 - 03/2007
3Multiple Myeloma
02/2018 - 01/2013
3Fabry Disease (Fabry's Disease)
11/2009 - 01/2006
3Mucolipidoses (Sialidosis)
04/2006 - 01/2002
2Inflammation (Inflammations)
06/2022 - 01/2018
2Neurologic Manifestations (Neurological Manifestations)
10/2011 - 04/2011
2Prostatic Neoplasms (Prostate Cancer)
06/2011 - 03/2011
2Metabolic Diseases (Metabolic Disease)
04/2011 - 04/2008
2Costello Syndrome
08/2008 - 08/2006
1Neuroinflammatory Diseases
06/2022
1Edema (Dropsy)
06/2022
1Breast Neoplasms (Breast Cancer)
07/2021
1Hyperthermia
02/2018
1Inborn Genetic Diseases (Disease, Hereditary)
01/2018
1Gliosis
01/2017
1Human Influenza (Influenza)
10/2011
1Disease Progression
10/2011
1Interstitial Cystitis (Interstitial Cystitis, Chronic)
11/2009
1Hypersensitivity (Allergy)
11/2009
1Neurodegenerative Diseases (Neurodegenerative Disease)
11/2009

Drug/Important Bio-Agent (IBA)

13G(M2) Ganglioside (Ganglioside GM2)IBA
01/2018 - 03/2005
12Proteins (Proteins, Gene)FDA Link
06/2022 - 01/2002
10EnzymesIBA
11/2018 - 01/2002
7Cathepsin AIBA
06/2022 - 01/2002
7beta-N-AcetylhexosaminidasesIBA
08/2010 - 03/2005
6Neuraminidase (Sialidase)IBA
01/2019 - 01/2002
5Hexosaminidases (Hexosaminidase)IBA
01/2017 - 01/2011
4ChemokinesIBA
06/2022 - 03/2005
4Pharmaceutical PreparationsIBA
02/2018 - 01/2011
4Hexosaminidase BIBA
01/2018 - 06/2011
4Hexosaminidase A (Hex A)IBA
01/2016 - 01/2011
4Mannose (D-Mannose)IBA
01/2016 - 05/2004
4GangliosidesIBA
10/2011 - 03/2007
4OligosaccharidesIBA
01/2011 - 03/2005
4Messenger RNA (mRNA)IBA
08/2008 - 02/2006
45'-deoxy-5'-phosphonomethyladenosine phosphateIBA
04/2006 - 01/2002
3Therapeutic UsesIBA
02/2018 - 08/2006
3Complementary DNA (cDNA)IBA
04/2006 - 01/2002
2sialooligosaccharidesIBA
01/2018 - 04/2006
2AutoantibodiesIBA
01/2017 - 10/2011
2Monoclonal AntibodiesIBA
01/2013 - 03/2007
2Fluorouracil (Carac)FDA LinkGeneric
06/2011 - 03/2011
2Biomarkers (Surrogate Marker)IBA
01/2011 - 12/2006
2Polysaccharides (Glycans)IBA
08/2010 - 09/2009
2AcetylglucosamineIBA
06/2009 - 09/2005
2Imino SugarsIBA
04/2009 - 05/2008
2alpha-Galactosidase (Beano)IBA
04/2009 - 01/2006
2TropoelastinIBA
08/2008 - 08/2006
2GlycoconjugatesIBA
04/2008 - 03/2005
2beta-Galactosidase (Lactaid)IBA
04/2006 - 05/2004
1TriterpenesIBA
07/2021
1GalactosidasesIBA
01/2019
1AdenineFDA LinkGeneric
11/2018
1GuanineIBA
11/2018
1GlycosphingolipidsIBA
01/2018
1Fc Receptors (Fc Receptor)IBA
01/2018
1Fingolimod Hydrochloride (FTY720)FDA Link
01/2017
1Immunosuppressive Agents (Immunosuppressants)IBA
01/2017
1G(M2) Activator ProteinIBA
09/2016
1Uridine Diphosphate (UDP)IBA
01/2016
1Fluorescent Dyes (Fluorescent Probes)IBA
01/2016
1Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA
01/2016
1Peptide Hydrolases (Proteases)FDA Link
01/2016
1Lactic Acid (Lactate)FDA LinkGeneric
10/2015
1Oseltamivir (Tamiflu)FDA Link
10/2011
1Zanamivir (Relenza)FDA Link
10/2011
1N-Acetylneuraminic Acid (Sialic Acid)IBA
10/2011
1CorticosteroneIBA
10/2011
1AndrogensIBA
06/2011
1Insulin-Like PeptidesIBA
06/2011
1Insulin-Like Growth Factor Binding Protein 3IBA
06/2011
1Androgen Receptors (Androgen Receptor)IBA
03/2011
1Hormones (Hormone)IBA
03/2011
1Thymidylate SynthaseIBA
03/2011
1hydroxyflutamideIBA
03/2011
1bicalutamide (Casodex)FDA LinkGeneric
03/2011
1Dinoprostone (PGE2)FDA Link
01/2011
1ATP-Binding Cassette Transporters (ABC Transporters)IBA
01/2011
1lysoganglioside G(M2)IBA
01/2011
1Doxorubicin (Adriamycin)FDA LinkGeneric
01/2011
1Daunorubicin (Cerubidine)FDA LinkGeneric
01/2011
1Adenosine Triphosphate (ATP)IBA
01/2011
1phenylacetylglutamineIBA
11/2009
1alpha-N-Acetylgalactosaminidase (N-Acetyl-alpha-D-Galactosaminidase)IBA
11/2009
1Enzyme Precursors (Zymogens)IBA
11/2009
1globotriaosylceramide (globotriosylceramide)IBA
11/2009
1Interleukin-8 (Interleukin 8)IBA
08/2008
1CytokinesIBA
08/2008
1Proteoglycans (Proteoglycan)IBA
08/2008
1CollagenIBA
08/2008
1Interleukin-1beta (Interleukin 1 beta)IBA
08/2008
1alpha-Glucosidases (Acid Maltase)IBA
05/2008

Therapy/Procedure

9Enzyme Replacement Therapy
01/2016 - 05/2004
7Therapeutics
09/2016 - 01/2005
1Castration
06/2011